3-Neurotransmitters, 1-Molecule: Optimized Ratios

Norepinephrine (NE), dopamine (DA) and serotonin (5-HT) are three important chemical messengers or neurotransmitters (also called “monoamines” based on their chemical structure) in the central nervous system. These neurotransmitters are generally associated with focus/attention, motivation/reward and mood.

Our technology allows us to “tune” the interactions of 5-HT, NE and DA with compounds having varying ratios of affinity for the three transporters.

The Role of Reuptake Inhibition

Our reuptake inhibitors can selectively affect the amount of each neurotransmitter in the brain. The availability of these monoamines at the synapses in the brain depends on the level of activity of transporter proteins that “transport” or clear their respective neurotransmitters. By inhibiting the transporter proteins, the neurotransmitters are left in place so that their concentration increases. Increased concentration of the neurotransmitters increases their activity. This process is referred to as reuptake inhibition.

Neurovanceʼs “triple” reuptake inhibitor centanafadine (formerly EB-1020) affects norepinephrine, dopamine and serotonin. Centanafadine (CTN) is being developed for Attention Deficit Hyperactivity Disorder (ADHD).

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